Function
Vacuolar protein sorting-associated protein (Vps) are part of Endosomal Sorting Complex Required for Transport (ESCRT) that performs the topologically unique membrane bending and scission reaction away from the cytoplasm. This process is required for the multivesicular body pathway, cytokinesis and HIV budding. There are five distinct ESCRT complexes (0,I,II,III,Vps4) with distinct functions[1].
- Vps4, Vps4A, Vps4B complex catalyzes the disassembly of the ESCRT-III filament in an ATP-driven reaction. Vps4 proteins are required for centrosome and spindle maintenance[2].
- Vps9A activates Rab5 to GTP-bound form[3].
- Vps15 may function as a G protein β subunit at the endosome [4].
- Vps23 is part of the ESCRT-I complex
- Vps25 is part of the ESCRT-II complex
- Vps27 is part of the ESCRT-0 complex
- Vps36 is part of the ESCRT-II complex
Disease
Relevance
Structural highlights