6ei6

Structural highlights

Function

[C2D1_DROME] Negative regulator of the Notch signaling pathway, acting to restrict the activity of Notch to the dorsoventral (D/V) boundary of the wing imaginal disk. Also causes negative regulation of Notch during vein, eye, and bristle development. Acts by targeting Notch for endosomal degradation or recycling.^{[1] [2]}

References

1. ↑ Klein T. The tumour suppressor gene l(2)giant discs is required to restrict the activity of Notch to the dorsoventral boundary during Drosophila wing development. Dev Biol. 2003 Mar 15;255(2):313-33. PMID:12648493
2. ↑ Childress JL, Acar M, Tao C, Halder G. Lethal giant discs, a novel C2-domain protein, restricts notch activation during endocytosis. Curr Biol. 2006 Nov 21;16(22):2228-33. Epub 2006 Nov 9. PMID:17088062 doi:http://dx.doi.org/S0960-9822(06)02224-X