3jrr

Structural highlights

Function

[ITPR3_MOUSE] Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.^{[1] [2]}

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

• Inositol 1%2C4%2C5-Trisphosphate Receptor

References

1. ↑ Yamazaki H, Chan J, Ikura M, Michikawa T, Mikoshiba K. Tyr-167/Trp-168 in type 1/3 inositol 1,4,5-trisphosphate receptor mediates functional coupling between ligand binding and channel opening. J Biol Chem. 2010 Nov 12;285(46):36081-91. doi: 10.1074/jbc.M110.140129. Epub, 2010 Sep 2. PMID:20813840 doi:http://dx.doi.org/10.1074/jbc.M110.140129
2. ↑ Giorgi C, Ito K, Lin HK, Santangelo C, Wieckowski MR, Lebiedzinska M, Bononi A, Bonora M, Duszynski J, Bernardi R, Rizzuto R, Tacchetti C, Pinton P, Pandolfi PP. PML regulates apoptosis at endoplasmic reticulum by modulating calcium release. Science. 2010 Nov 26;330(6008):1247-51. doi: 10.1126/science.1189157. Epub 2010, Oct 28. PMID:21030605 doi:http://dx.doi.org/10.1126/science.1189157