6al3

Structural highlights

Function

[PA2B2_PROFL] Snake venom phospholipase A2 (PLA2) that shows anticoagulant activities, strong myolytic activity, infiltration of polymorphonuclear cells, and edema in stromal tissues. Induces cell death of Jurkat cells in a concentration dependent manner. Shows a low phospholipase A2 activity. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.^{[1] [2]}

References

1. ↑ Murakami T, Kariu T, Takazaki S, Hattori S, Chijiwa T, Ohno M, Oda-Ueda N. Island specific expression of a novel [Lys(49)]phospholipase A(2) (BPIII) in Protobothrops flavoviridis venom in Amami-Oshima, Japan. Toxicon. 2009 Sep 15;54(4):399-407. doi: 10.1016/j.toxicon.2009.05.003. Epub 2009, May 20. PMID:19463843 doi:http://dx.doi.org/10.1016/j.toxicon.2009.05.003
2. ↑ Liu SY, Yoshizumi K, Oda N, Ohno M, Tokunaga F, Iwanaga S, Kihara H. Purification and amino acid sequence of basic protein II, a lysine-49-phospholipase A2 with low activity, from Trimeresurus flavoviridis venom. J Biochem. 1990 Mar;107(3):400-8. PMID:2341374