Structural highlights
Publication Abstract from PubMed
The crystal structure of the Delta,Delta enantiomer of the binuclear "light-switch" ruthenium complex [mu-(11,11'-bidppz)(1,10-phenanthroline)4 Ru2 ](4+) bound to the oligonucleotide d(CGTACG) shows that one dppz moiety of the dumbbell-like compound inserts into the DNA stack through the extrusion of an AT base pair. The second dppz moiety recruits a neighboring DNA molecule, and the complex thus cross-links two adjacent duplexes by bridging their major grooves.
Thread insertion of a bis(dipyridophenazine) diruthenium complex into the DNA double helix by the extrusion of AT base pairs and cross-linking of DNA duplexes.,Boer DR, Wu L, Lincoln P, Coll M Angew Chem Int Ed Engl. 2014 Feb 10;53(7):1949-52. doi: 10.1002/anie.201308070., Epub 2014 Jan 21. PMID:24449275[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Boer DR, Wu L, Lincoln P, Coll M. Thread insertion of a bis(dipyridophenazine) diruthenium complex into the DNA double helix by the extrusion of AT base pairs and cross-linking of DNA duplexes. Angew Chem Int Ed Engl. 2014 Feb 10;53(7):1949-52. doi: 10.1002/anie.201308070., Epub 2014 Jan 21. PMID:24449275 doi:http://dx.doi.org/10.1002/anie.201308070
