Structural highlights
Function
[ASNA1_CHLRE] ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the chloroplast. Required for the accumulation of TOC34, an essential component of the outer chloroplast membrane translocon (TOC) complex (PubMed:23167510, PubMed:28382961). Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to chloroplast, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis (PubMed:28382961).[1] [2]
References
- ↑ Formighieri C, Cazzaniga S, Kuras R, Bassi R. Biogenesis of photosynthetic complexes in the chloroplast of Chlamydomonas reinhardtii requires ARSA1, a homolog of prokaryotic arsenite transporter and eukaryotic TRC40 for guided entry of tail-anchored proteins. Plant J. 2013 Mar;73(5):850-61. doi: 10.1111/tpj.12077. Epub 2012 Dec 28. PMID:23167510 doi:http://dx.doi.org/10.1111/tpj.12077
- ↑ Maestre-Reyna M, Wu SM, Chang YC, Chen CC, Maestre-Reyna A, Wang AH, Chang HY. In search of tail-anchored protein machinery in plants: reevaluating the role of arsenite transporters. Sci Rep. 2017 Apr 6;7:46022. doi: 10.1038/srep46022. PMID:28382961 doi:http://dx.doi.org/10.1038/srep46022
