Structural highlights
Publication Abstract from PubMed
Getting to the heart of it: Co-crystallization of an RNA three-way junction with a cylindrical di-iron(II)-based anti-cancer drug (green) results in pi-stacking interactions between the cylinder and the central base pairs of the RNA structure. The shape, size, and cationic nature of the cylinder were found to be responsible for this perfect fit. Native gel electrophoresis studies confirmed stabilization of the RNA three-way junction by the iron(II) cylinder.
Binding of a Designed Anti-cancer Drug to the Central Cavity of an RNA Three-Way Junction.,Phongtongpasuk S, Paulus S, Schnabl J, Sigel RK, Spingler B, Hannon MJ, Freisinger E Angew Chem Int Ed Engl. 2013 Aug 23. doi: 10.1002/anie.201305079. PMID:24039102[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Phongtongpasuk S, Paulus S, Schnabl J, Sigel RK, Spingler B, Hannon MJ, Freisinger E. Binding of a Designed Anti-cancer Drug to the Central Cavity of an RNA Three-Way Junction. Angew Chem Int Ed Engl. 2013 Aug 23. doi: 10.1002/anie.201305079. PMID:24039102 doi:10.1002/anie.201305079
