Structural highlights
4iye is a 1 chain structure with sequence from Denan. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Ligands: | , |
| Related: | 2vlw, 3fev, 3neq, 4do8, 1ff4, 2h5f, 2h7z |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Publication Abstract from PubMed
rho-Da1a toxin from eastern green mamba (Dendroaspis angusticeps) venom is a polypeptide of 65 amino acids with a strong affinity for the G-protein-coupled alpha(1A)-adrenoceptor. This neurotoxin has been crystallized from resolubilized lyophilized powder, but the best crystals grew spontaneously during lyophilization. The crystals belonged to the trigonal space group P3(1)21, with unit-cell parameters a = b = 37.37, c = 66.05 A, and diffracted to 1.95 A resolution. The structure solved by molecular replacement showed strong similarities to green mamba muscarinic toxins.
Crystallization of recombinant green mamba rho-Da1a toxin during a lyophilization procedure and its structure determination.,Maiga A, Vera L, Marchetti C, Lorphelin A, Bellanger L, Mourier G, Servent D, Gilles N, Stura EA Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Jun;69(Pt 6):704-9. doi:, 10.1107/S1744309113011470. Epub 2013 May 29. PMID:23722859[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Maiga A, Vera L, Marchetti C, Lorphelin A, Bellanger L, Mourier G, Servent D, Gilles N, Stura EA. Crystallization of recombinant green mamba rho-Da1a toxin during a lyophilization procedure and its structure determination. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Jun;69(Pt 6):704-9. doi:, 10.1107/S1744309113011470. Epub 2013 May 29. PMID:23722859 doi:10.1107/S1744309113011470
