Function
Beta-ketoacyl carrier protein reductase (BKACPR) catalyzes the reaction of conversion of 3-hydroxyacyl-[acyl-carrier-protein] to 3-oxoacyl-[acyl-carrier-protein] while using NADPH as a reducing agent. BKACPR is part of the type II fatty acid biosynthesis pathway. Pimelyl carrier protein reductase (ACPR) is involved in the assembly pathway of the pimeloyl moiety of biotin.
Relevance
BKACPR from Plasmodium falciparium inhibitors are tested as antimalarial drugs. Other BKACPR inhibitors are tested for combating toxoplasmosis and sleeping sickness.
Structural highlights
The interacting with co-factor NADPH contains the active site catalytic triad (in E. coli, PDB code 1q7b).[1] Water molecules are shown as red spheres.
3D structures of beta-ketoacyl carrier protein reductase
Beta-ketoacyl carrier protein reductase 3D structures
