5z1w

Structural highlights

Function

[PK2L1_MOUSE] Pore-forming subunit of a ciliary calcium channel that controls calcium concentration within primary cilia without affecting cytoplasmic calcium concentration. Forms a heterodimer with PKD1L1 in primary cilia and forms a calcium-permeant ciliary channel that regulates sonic hedgehog/SHH signaling and GLI2 transcription. May act as a sour taste receptor by forming a calcium channel with PKD1L3 in gustatory cells; however, its contribution to sour taste perception is unclear in vivo and may be indirect. May play a role in the perception of carbonation taste.^{[1] [2] [3] [4] [5] [6] [7] [8]}

References

1. ↑ Murakami M, Ohba T, Xu F, Shida S, Satoh E, Ono K, Miyoshi I, Watanabe H, Ito H, Iijima T. Genomic organization and functional analysis of murine PKD2L1. J Biol Chem. 2005 Feb 18;280(7):5626-35. doi: 10.1074/jbc.M411496200. Epub 2004, Nov 17. PMID:15548533 doi:http://dx.doi.org/10.1074/jbc.M411496200
2. ↑ Ishimaru Y, Inada H, Kubota M, Zhuang H, Tominaga M, Matsunami H. Transient receptor potential family members PKD1L3 and PKD2L1 form a candidate sour taste receptor. Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12569-74. doi:, 10.1073/pnas.0602702103. Epub 2006 Aug 4. PMID:16891422 doi:http://dx.doi.org/10.1073/pnas.0602702103
3. ↑ Huang AL, Chen X, Hoon MA, Chandrashekar J, Guo W, Trankner D, Ryba NJ, Zuker CS. The cells and logic for mammalian sour taste detection. Nature. 2006 Aug 24;442(7105):934-8. doi: 10.1038/nature05084. PMID:16929298 doi:http://dx.doi.org/10.1038/nature05084
4. ↑ Chandrashekar J, Yarmolinsky D, von Buchholtz L, Oka Y, Sly W, Ryba NJ, Zuker CS. The taste of carbonation. Science. 2009 Oct 16;326(5951):443-5. doi: 10.1126/science.1174601. PMID:19833970 doi:http://dx.doi.org/10.1126/science.1174601
5. ↑ Chang RB, Waters H, Liman ER. A proton current drives action potentials in genetically identified sour taste cells. Proc Natl Acad Sci U S A. 2010 Dec 21;107(51):22320-5. doi:, 10.1073/pnas.1013664107. Epub 2010 Nov 23. PMID:21098668 doi:http://dx.doi.org/10.1073/pnas.1013664107
6. ↑ Horio N, Yoshida R, Yasumatsu K, Yanagawa Y, Ishimaru Y, Matsunami H, Ninomiya Y. Sour taste responses in mice lacking PKD channels. PLoS One. 2011;6(5):e20007. doi: 10.1371/journal.pone.0020007. Epub 2011 May 19. PMID:21625513 doi:http://dx.doi.org/10.1371/journal.pone.0020007
7. ↑ Delling M, DeCaen PG, Doerner JF, Febvay S, Clapham DE. Primary cilia are specialized calcium signalling organelles. Nature. 2013 Dec 12;504(7479):311-4. doi: 10.1038/nature12833. PMID:24336288 doi:http://dx.doi.org/10.1038/nature12833
8. ↑ DeCaen PG, Delling M, Vien TN, Clapham DE. Direct recording and molecular identification of the calcium channel of primary cilia. Nature. 2013 Dec 12;504(7479):315-8. doi: 10.1038/nature12832. PMID:24336289 doi:http://dx.doi.org/10.1038/nature12832