Sandbox Reserved 1548

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This Sandbox is Reserved from May 28 through July 01, 2019 for use in the course Advanced Biochemistry BCHM 4100 taught by Tom Gluick at the Georgia Gwinnett College. This reservation includes Sandbox Reserved 1544 through Sandbox Reserved 1555.
To get started:
  • Click the edit this page tab at the top. Save the page after each step, then edit it again.
  • Click the 3D button (when editing, above the wikitext box) to insert Jmol.
  • show the Scene authoring tools, create a molecular scene, and save it. Copy the green link into the page.
  • Add a description of your scene. Use the buttons above the wikitext box for bold, italics, links, headlines, etc.

More help: Help:Editing

Contents

Transitionally controlled tumor protein 1 (TCTP1/TPT1)

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Drag the structure with the mouse to rotate

TCTP1 is a highly conserved essential anti-apoptotic protein that is known to play a key role in tumor growth. High levels of expression TCTP1 is commonly seen in dividing cells, and it is overexpressed in tumor cells. Decreased expression of TCTP1 in malignant cells has been identified as one possible mechanism of tumor reversion, where tumorgenic cancerous cells cease to be malignant.

While many mammals, including humans have one copy of TCTP1, the capybara, the largest rodent has multiple copies of the TCTP1 gene. It is hypothesized that these multiple copies are one mechanism of cell proliferation and growth. You may include any references to papers as in: the use of JSmol in Proteopedia [1] or to the article describing Jmol [2] to the rescue.

Function

Disease

Relevance

Structural highlights

TCTP has three α helices and nine β sheets.

This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

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References

  1. ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
  2. ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
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