Casein kinase

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spinqualitylabelsall models Human casein kinase 1 γ3 complex with inhibitor (PDB code 4g16) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Contents 1 Function 2 Structural highlights Function Casein kinase (CK) is a protein kinase which functions as regulator of signal transduction. CK1 is a serine/threonine kinase with several members: α, β1, γ1, γ2, γ3, δ and ε.[1] CK2 functions in cell cycle control, DNA repair and circadian rhythm regulation.[2] Structural highlights CK2 is a tetramer with a pair of 2 subunits – the α subunit is the catalytic one and the β subunit is the regulatory one. . [3] Water molecules are shown as red spheres.

3D Structures of casein kinase

Updated on 01-March-2019

References

1. ↑ Eide EJ, Virshup DM. Casein kinase I: another cog in the circadian clockworks. Chronobiol Int. 2001 May;18(3):389-98. PMID:11475410
2. ↑ Pinna LA, Meggio F. Protein kinase CK2 ("casein kinase-2") and its implication in cell division and proliferation. Prog Cell Cycle Res. 1997;3:77-97. PMID:9552408
3. ↑ Hua Z, Huang X, Bregman H, Chakka N, DiMauro EF, Doherty EM, Goldstein J, Gunaydin H, Huang H, Mercede S, Newcomb J, Patel VF, Turci SM, Yan J, Wilson C, Martin MW. 2-Phenylamino-6-cyano-1H-benzimidazole-based isoform selective casein kinase 1 gamma (CK1gamma) inhibitors. Bioorg Med Chem Lett. 2012 Sep 1;22(17):5392-5. doi: 10.1016/j.bmcl.2012.07.046. , Epub 2012 Jul 20. PMID:22877629 doi:10.1016/j.bmcl.2012.07.046