Sandbox Reserved 1548

From Proteopedia

Revision as of 17:29, 29 April 2019 by Sarah Marks (Talk | contribs)
Jump to: navigation, search
This Sandbox is Reserved from May 28 through July 01, 2019 for use in the course Advanced Biochemistry BCHM 4100 taught by Tom Gluick at the Georgia Gwinnett College. This reservation includes Sandbox Reserved 1544 through Sandbox Reserved 1555.
To get started:
  • Click the edit this page tab at the top. Save the page after each step, then edit it again.
  • Click the 3D button (when editing, above the wikitext box) to insert Jmol.
  • show the Scene authoring tools, create a molecular scene, and save it. Copy the green link into the page.
  • Add a description of your scene. Use the buttons above the wikitext box for bold, italics, links, headlines, etc.

More help: Help:Editing

Contents

Transitionally controlled tumor protein 1 (TCTP1/TPT1)

Insert caption here

Drag the structure with the mouse to rotate

You may include any references to papers as in: the use of JSmol in Proteopedia [1] or to the article describing Jmol [2] to the rescue.

Function

TCTP1 is a highly conserved essential anti-apoptotic protein that is known to play a key role in tumor growth. High levels of expression TCTP1 are commonly seen in dividing cells, and it is overexpressed in tumor cells. [3] Decreased expression of TCTP1 in malignant cells has been identified as one possible mechanism of tumor reversion, where tumorgenic cancerous cells cease to be malignant. Specifically, TCTP1 expression is almost undetectable in reverted cells. [4]

Multiple proposed mechanisms have been proposed to explain TCTP1's ability to help regulate tumorgenic activity. TCTP1 may interact with the pro-apoptotic factor Bax.

While many mammals, including humans have one copy of TCTP1, the capybara, the largest rodent has multiple copies of the TCTP1 gene. It is hypothesized that these multiple copies are one mechanism of cell proliferation and growth that enables the capybara to achieve such a large size.

Disease

Relevance

Structural highlights

TCTP has three α helices and nine β strands arranged into two distorted β sheets.

TCTP1 is hypothesized to interact with Bax which has two helices (H5-H6) that are structurally very similar to the H2/H3 in TCTP1.

This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

</StructureSection>

References

  1. ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
  2. ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
  3. ↑ . PMID:216315890657
  4. ↑ . PMID:216315890657
Retrieved from "http://52.214.119.220/wiki/index.php/Sandbox_Reserved_1548"
Personal tools