6c3r

Structural highlights

Function

[POLN_CRPVC] Protein 1A functions as a suppressor of RNA-mediated gene silencing, an antiviral defense mechanism of insect cells. Inhibits siRNA function, but does not interfere with miRNA pathway. Does not bind to dsRNA or siRNA.^[1] RNA-directed RNA polymerase replicates genomic and antigenomic RNA.[PROSITE-ProRule:PRU00539]^[2]

References

1. ↑ Nayak A, Berry B, Tassetto M, Kunitomi M, Acevedo A, Deng C, Krutchinsky A, Gross J, Antoniewski C, Andino R. Cricket paralysis virus antagonizes Argonaute 2 to modulate antiviral defense in Drosophila. Nat Struct Mol Biol. 2010 May;17(5):547-54. doi: 10.1038/nsmb.1810. Epub 2010 Apr, 18. PMID:20400949 doi:http://dx.doi.org/10.1038/nsmb.1810
2. ↑ Nayak A, Berry B, Tassetto M, Kunitomi M, Acevedo A, Deng C, Krutchinsky A, Gross J, Antoniewski C, Andino R. Cricket paralysis virus antagonizes Argonaute 2 to modulate antiviral defense in Drosophila. Nat Struct Mol Biol. 2010 May;17(5):547-54. doi: 10.1038/nsmb.1810. Epub 2010 Apr, 18. PMID:20400949 doi:http://dx.doi.org/10.1038/nsmb.1810