Structural highlights
4r45 is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Ligands: | |
| Related: | 4r44, 4r47, 4r48, 4r49, 4r4a, 4r4d |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Publication Abstract from PubMed
Racemates increase the chances of crystallization by allowing molecular contacts to be formed in a greater number of ways. With the advent of protein synthesis, the production of protein racemates and racemic-protein crystallography are now possible. Curiously, racemic DNA crystallography had not been investigated despite the commercial availability of L- and D-deoxyribo-oligonucleotides. Here, we report a study into racemic DNA crystallography showing the strong propensity of racemic DNA mixtures to form racemic crystals. We describe racemic crystal structures of various DNA sequences and folded conformations, including duplexes, quadruplexes, and a four-way junction, showing that the advantages of racemic crystallography should extend to DNA.
Racemic DNA Crystallography.,Mandal PK, Collie GW, Kauffmann B, Huc I Angew Chem Int Ed Engl. 2014 Oct 30. doi: 10.1002/anie.201409014. PMID:25358289[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Mandal PK, Collie GW, Kauffmann B, Huc I. Racemic DNA Crystallography. Angew Chem Int Ed Engl. 2014 Oct 30. doi: 10.1002/anie.201409014. PMID:25358289 doi:http://dx.doi.org/10.1002/anie.201409014
