Structural highlights
Publication Abstract from PubMed
A G-quadruplex adopting a (3 + 1)-hybrid structure was substituted at its 5'-tetrad by 2'-deoxy-2'-fluoro-arabinoguanosine (FaraG) analogs. Incorporation of anti-favoring FaraG at syn-positions of the 5'-outer tetrad induced a reversal of the tetrad polarity without noticeably compromising the quadruplex stability. This conformational change is shown to be promoted by nonconventional C-H...F hydrogen bonds acting within the anti-FaraG residues.
Nonconventional C-H...F Hydrogen Bonds Support a Tetrad Flip in Modified G-Quadruplexes.,Dickerhoff J, Weisz K J Phys Chem Lett. 2017 Oct 6:5148-5152. doi: 10.1021/acs.jpclett.7b02428. PMID:28976755[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Dickerhoff J, Weisz K. Nonconventional C-H...F Hydrogen Bonds Support a Tetrad Flip in Modified G-Quadruplexes. J Phys Chem Lett. 2017 Oct 6:5148-5152. doi: 10.1021/acs.jpclett.7b02428. PMID:28976755 doi:http://dx.doi.org/10.1021/acs.jpclett.7b02428
