Structural highlights
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
The structure of the antibody Fab fragment f3p4, which was selected from a subset of the synthetic HuCAL antibody library to bind the sodium citrate symporter CitS, is described at 1.92 A resolution. Comparison with computational models revealed deviations in a few framework positions and in the binding loops. The crystals belong to space group P2(1)2(1)2 and contain four molecules in the asymmetric unit, with unit-cell parameters a=102.77, b=185.92, c=102.97 A. These particular unit-cell parameters allowed pseudo-merohedral twinning; interestingly, the twinning law relates a twofold screw axis to a twofold axis.
Structure of the recombinant antibody Fab fragment f3p4.,Frey D, Huber T, Pluckthun A, Grutter MG Acta Crystallogr D Biol Crystallogr. 2008 Jun;64(Pt 6):636-43. Epub 2008 May 14. PMID:18560151[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Frey D, Huber T, Pluckthun A, Grutter MG. Structure of the recombinant antibody Fab fragment f3p4. Acta Crystallogr D Biol Crystallogr. 2008 Jun;64(Pt 6):636-43. Epub 2008 May 14. PMID:18560151 doi:10.1107/S0907444908007282
