6ivs

Structural highlights

Function

[RSGI1_CLOTH] Anti-sigma factor for SigI1. Negatively regulates SigI1 activity through direct interaction (PubMed:20937888). Binding of the polysaccharide substrate to the extracellular C-terminal sensing domain of RsgI1 may induce a conformational change in its N-terminal cytoplasmic region, leading to the release and activation of SigI1 (Probable).^{[1] [2]}

References

1. ↑ Nataf Y, Bahari L, Kahel-Raifer H, Borovok I, Lamed R, Bayer EA, Sonenshein AL, Shoham Y. Clostridium thermocellum cellulosomal genes are regulated by extracytoplasmic polysaccharides via alternative sigma factors. Proc Natl Acad Sci U S A. 2010 Oct 26;107(43):18646-51. doi:, 10.1073/pnas.1012175107. Epub 2010 Oct 11. PMID:20937888 doi:http://dx.doi.org/10.1073/pnas.1012175107
2. ↑ Nataf Y, Bahari L, Kahel-Raifer H, Borovok I, Lamed R, Bayer EA, Sonenshein AL, Shoham Y. Clostridium thermocellum cellulosomal genes are regulated by extracytoplasmic polysaccharides via alternative sigma factors. Proc Natl Acad Sci U S A. 2010 Oct 26;107(43):18646-51. doi:, 10.1073/pnas.1012175107. Epub 2010 Oct 11. PMID:20937888 doi:http://dx.doi.org/10.1073/pnas.1012175107