Function
Eukaryotic initiation factors (EIF) are involved in the initiation of protein translation. They form a complex with the small subunit of the ribosome and Met-tRNA which scans the mRNA and recognizes the initiation codon AUG[1]. For details on EIF4 see C-terminal portion of human eIF4GI.
Disease
Overexpression of individual subunits of eIF3 may cause malignant transformation [2]. Overexpression of eIF4g is implicated in breast cancer.
Structural insights
EIF domains include the N terminal domain (NTD), C terminal domain (CTD), RNA recognition domain, middle domain, PAZ domain of EIF2C and a protein-protein interaction domain (PCI) of EIF3.
- . Water molecules shown as red spheres.
3D structures of eukaryotic initiation factor
Eukaryotic initiation factor 3D structures
