Structural highlights
Function
[FRIL_HORSE] Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).
Publication Abstract from PubMed
A set of three catecholamide ligands mimicking the structure of enterobactin was constructed on ferritin, where the 3-fold symmetric arrangement of the monomer subunits served as a foundation to form a coordination space. Similar to enterobactin, the ligands showed strong affinity for the ferric ion and formed a tris-catechoyl complex. Crystallography revealed that the complex was embedded in the entrance of the 3-fold axis channel.
Construction of an enterobactin analogue with symmetrically arranged monomer subunits of ferritin.,Nakajima H, Kondo M, Nakane T, Abe S, Nakao T, Watanabe Y, Ueno T Chem Commun (Camb). 2015 Dec 4;51(93):16609-12. doi: 10.1039/c5cc06904a. Epub, 2015 Sep 25. PMID:26404005[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Nakajima H, Kondo M, Nakane T, Abe S, Nakao T, Watanabe Y, Ueno T. Construction of an enterobactin analogue with symmetrically arranged monomer subunits of ferritin. Chem Commun (Camb). 2015 Dec 4;51(93):16609-12. doi: 10.1039/c5cc06904a. Epub, 2015 Sep 25. PMID:26404005 doi:http://dx.doi.org/10.1039/c5cc06904a
