6ra0

Structural highlights

Function

[DKF1_CAEEL] Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, independently of PKC (PubMed:16613841, PubMed:16613842). Role in the regulation of growth and neuromuscular control of movement (PubMed:16613841, PubMed:16613842). Involved in immune response to S.aureus bacterium by activating transcription factor hlh-30 downstream of phospholipase plc-1 (PubMed:27184844).^{[1] [2] [3]}

References

1. ↑ Feng H, Ren M, Wu SL, Hall DH, Rubin CS. Characterization of a novel protein kinase D: Caenorhabditis elegans DKF-1 is activated by translocation-phosphorylation and regulates movement and growth in vivo. J Biol Chem. 2006 Jun 30;281(26):17801-14. doi: 10.1074/jbc.M511899200. Epub 2006, Apr 13. PMID:16613841 doi:http://dx.doi.org/10.1074/jbc.M511899200
2. ↑ Feng H, Ren M, Rubin CS. Conserved domains subserve novel mechanisms and functions in DKF-1, a Caenorhabditis elegans protein kinase D. J Biol Chem. 2006 Jun 30;281(26):17815-26. doi: 10.1074/jbc.M511898200. Epub 2006, Apr 13. PMID:16613842 doi:http://dx.doi.org/10.1074/jbc.M511898200
3. ↑ Najibi M, Labed SA, Visvikis O, Irazoqui JE. An Evolutionarily Conserved PLC-PKD-TFEB Pathway for Host Defense. Cell Rep. 2016 May 24;15(8):1728-42. doi: 10.1016/j.celrep.2016.04.052. Epub 2016, May 12. PMID:27184844 doi:http://dx.doi.org/10.1016/j.celrep.2016.04.052