5h9b

Structural highlights

Function

[KCNAE_DROME] Structural component of a potassium channel. Mediates the potassium permeability of membranes; potassium current is regulated by CaMKII and CASK. Has a role in growth of the perineurial glial layer of the larval peripheral nerve.^{[1] [2] [3] [4]}

References

1. ↑ Yager J, Richards S, Hekmat-Scafe DS, Hurd DD, Sundaresan V, Caprette DR, Saxton WM, Carlson JR, Stern M. Control of Drosophila perineurial glial growth by interacting neurotransmitter-mediated signaling pathways. Proc Natl Acad Sci U S A. 2001 Aug 28;98(18):10445-50. Epub 2001 Aug 21. PMID:11517334 doi:http://dx.doi.org/10.1073/pnas.191107698
2. ↑ Wang Z, Wilson GF, Griffith LC. Calcium/calmodulin-dependent protein kinase II phosphorylates and regulates the Drosophila eag potassium channel. J Biol Chem. 2002 Jul 5;277(27):24022-9. Epub 2002 Apr 29. PMID:11980904 doi:http://dx.doi.org/10.1074/jbc.M201949200
3. ↑ Marble DD, Hegle AP, Snyder ED 2nd, Dimitratos S, Bryant PJ, Wilson GF. Camguk/CASK enhances Ether-a-go-go potassium current by a phosphorylation-dependent mechanism. J Neurosci. 2005 May 18;25(20):4898-907. PMID:15901771 doi:http://dx.doi.org/10.1523/JNEUROSCI.4566-04.2005
4. ↑ Warmke J, Drysdale R, Ganetzky B. A distinct potassium channel polypeptide encoded by the Drosophila eag locus. Science. 1991 Jun 14;252(5012):1560-2. PMID:1840699