| Structural highlights
Function
[PKHA8_HUMAN] Cargo transport protein that is required for apical transport from the Golgi complex. Transports AQP2 from the trans-Golgi network (TGN) to sites of AQP2 phosphorylation. Mediates the non-vesicular transport of glucosylceramide (GlcCer) from the trans-Golgi network (TGN) to the plasma membrane and plays a pivotal role in the synthesis of complex glycosphingolipids. Binding of both phosphatidylinositol 4-phosphate (PIP) and ARF1 are essential for the GlcCer transfer ability. Also required for primary cilium formation, possibly by being involved in the transport of raft lipids to the apical membrane, and for membrane tubulation.[1] [2] [3]
References
- ↑ Godi A, Di Campli A, Konstantakopoulos A, Di Tullio G, Alessi DR, Kular GS, Daniele T, Marra P, Lucocq JM, De Matteis MA. FAPPs control Golgi-to-cell-surface membrane traffic by binding to ARF and PtdIns(4)P. Nat Cell Biol. 2004 May;6(5):393-404. Epub 2004 Apr 25. PMID:15107860 doi:10.1038/ncb1119
- ↑ Vieira OV, Verkade P, Manninen A, Simons K. FAPP2 is involved in the transport of apical cargo in polarized MDCK cells. J Cell Biol. 2005 Aug 15;170(4):521-6. doi: 10.1083/jcb.200503078. PMID:16103222 doi:http://dx.doi.org/10.1083/jcb.200503078
- ↑ D'Angelo G, Polishchuk E, Di Tullio G, Santoro M, Di Campli A, Godi A, West G, Bielawski J, Chuang CC, van der Spoel AC, Platt FM, Hannun YA, Polishchuk R, Mattjus P, De Matteis MA. Glycosphingolipid synthesis requires FAPP2 transfer of glucosylceramide. Nature. 2007 Sep 6;449(7158):62-7. doi: 10.1038/nature06097. Epub 2007 Aug 8. PMID:17687330 doi:http://dx.doi.org/10.1038/nature06097
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