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Function
Riboswitches regulate the synthesis of proteins and are controlled by thiamine pyrophosphate.[3] They are usually found within non-coding portions of messenger RNAs.[3]Thiamine pyrophosphate is also known as TPP. TPP is essential in all three domains of life, including: bacteria, fungi, and plants. [3] They use this specific riboswitch to control genes that are in charge of synthesizing thiamine and any phosphorylated derivatives.[3]TPP and its riboswitch work together to directly regulate the synthesis of a protein related to TPP. [3]Thiamine pyrophosphate is the most widely distributed riboswitch of the metabolite-sensing RNA regulatory system. [3] The reason for this is because TPP is a form of vitamin B1, and vitamin B1 takes an essential part in many protein-catalyzed reactions; thus it is used quite often. zack is right
Magnesium Link
PAPER CITATION: [4]
TPP Link
Disease
Relevance
Structural highlights
TPP riboswitches were one of the first of several classes found to form successful interactions with negatively charged phosphate groups.[3]
TPP's pyrophosphate group is bound by a pair of Mg2+ ions, . [3] TPP's terminal phosphate group is coordinately bonded to both , but the thiazole-linked phosphate is only coordinately bonded to Mg2.[3]
Holding Mg1 in place are and they can be found within the region that previously was known for pyrophosphate recognition.[3] Structures of proteins bound to TPP typically position Mg2+, Ca2+, or Mn2+ ions using charged amino acids, in a site equivalent .[3] However, the TPP riboswitch is the only riboswitch that contains the Mg1 ion.[3]
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