6kks

Structural highlights

Function

[WER_ARATH] Transcription activator, when associated with BHLH2/EGL3/MYC146 or BHLH12/MYC1. Involved in epidermal cell fate specification in roots and hypocotyl. Together with GL3 or BHLH2, promotes the formation of non-hair developing cells (atrichoblasts) et the N position in root epidermis. Regulates stomata spatial distribution in hypocotyls. Binds to the WER-binding sites (WBS) promoter regions and activates the transcription of target genes such as GL2 and of CPC.^{[1] [2] [3] [4] [5] [6]}

References

1. ↑ Lee MM, Schiefelbein J. WEREWOLF, a MYB-related protein in Arabidopsis, is a position-dependent regulator of epidermal cell patterning. Cell. 1999 Nov 24;99(5):473-83. doi: 10.1016/s0092-8674(00)81536-6. PMID:10589676 doi:http://dx.doi.org/10.1016/s0092-8674(00)81536-6
2. ↑ Lin Y, Schiefelbein J. Embryonic control of epidermal cell patterning in the root and hypocotyl of Arabidopsis. Development. 2001 Oct;128(19):3697-705. PMID:11585796
3. ↑ Bernhardt C, Lee MM, Gonzalez A, Zhang F, Lloyd A, Schiefelbein J. The bHLH genes GLABRA3 (GL3) and ENHANCER OF GLABRA3 (EGL3) specify epidermal cell fate in the Arabidopsis root. Development. 2003 Dec;130(26):6431-9. Epub 2003 Nov 19. PMID:14627722 doi:http://dx.doi.org/10.1242/dev.00880
4. ↑ Zimmermann IM, Heim MA, Weisshaar B, Uhrig JF. Comprehensive identification of Arabidopsis thaliana MYB transcription factors interacting with R/B-like BHLH proteins. Plant J. 2004 Oct;40(1):22-34. doi: 10.1111/j.1365-313X.2004.02183.x. PMID:15361138 doi:http://dx.doi.org/10.1111/j.1365-313X.2004.02183.x
5. ↑ Koshino-Kimura Y, Wada T, Tachibana T, Tsugeki R, Ishiguro S, Okada K. Regulation of CAPRICE transcription by MYB proteins for root epidermis differentiation in Arabidopsis. Plant Cell Physiol. 2005 Jun;46(6):817-26. Epub 2005 Mar 28. PMID:15795220 doi:http://dx.doi.org/pci096
6. ↑ Ryu KH, Kang YH, Park YH, Hwang I, Schiefelbein J, Lee MM. The WEREWOLF MYB protein directly regulates CAPRICE transcription during cell fate specification in the Arabidopsis root epidermis. Development. 2005 Nov;132(21):4765-75. Epub 2005 Oct 5. PMID:16207757 doi:http://dx.doi.org/dev.02055