6dja

Structural highlights

Function

[BLAB_BACCE] Confers resistance to the different beta-lactams antibiotics (penicillin, cephalosporin and carbapenem) via the hydrolysis of the beta-lactam ring. Benzylpenicillin is a better substrate than cephalosporin C and ampicillin (PubMed:3131315, PubMed:2501295).^{[1] [2] [3]}

References

1. ↑ Lim HM, Iyer RK, Pene JJ. Site-directed mutagenesis of dicarboxylic acids near the active site of Bacillus cereus 5/B/6 beta-lactamase II. Biochem J. 1991 Jun 1;276 ( Pt 2):401-4. PMID:1904717
2. ↑ Lim HM, Pene JJ. Mutations affecting the catalytic activity of Bacillus cereus 5/B/6 beta-lactamase II. J Biol Chem. 1989 Jul 15;264(20):11682-7. PMID:2501295
3. ↑ Lim HM, Pene JJ, Shaw RW. Cloning, nucleotide sequence, and expression of the Bacillus cereus 5/B/6 beta-lactamase II structural gene. J Bacteriol. 1988 Jun;170(6):2873-8. doi: 10.1128/jb.170.6.2873-2878.1988. PMID:3131315 doi:http://dx.doi.org/10.1128/jb.170.6.2873-2878.1988