6buo

Structural highlights

Function

[CAH_MOOTA] Responsible for the hydrolysis of cyanuric acid, an intermediate formed during catabolism of s-triazine based compounds in herbicides such as atrazine and polymers such as melamine. Catalyzes the hydrolytic opening of the s-triazine ring of cyanuric acid (2,4,6-trihydroxy-s-triazine) to yield carbon dioxide and carboxybiuret, which spontaneously decarboxylates to biuret.[HAMAP-Rule:MF_01989]^{[1] [2]}

References

1. ↑ Li Q, Seffernick JL, Sadowsky MJ, Wackett LP. Thermostable cyanuric acid hydrolase from Moorella thermoacetica ATCC 39073. Appl Environ Microbiol. 2009 Nov;75(22):6986-91. doi: 10.1128/AEM.01605-09. Epub , 2009 Sep 18. PMID:19767460 doi:http://dx.doi.org/10.1128/AEM.01605-09
2. ↑ Peat TS, Balotra S, Wilding M, Hartley CJ, Newman J, Scott C. High resolution X-ray structures of two functionally distinct members of the cyclic amide hydrolase (CyAH) family of Toblerone fold enzymes. Appl Environ Microbiol. 2017 Feb 24. pii: AEM.03365-16. doi:, 10.1128/AEM.03365-16. PMID:28235873 doi:http://dx.doi.org/10.1128/AEM.03365-16