5v3j

Structural highlights

Function

[ZN568_MOUSE] Has transcriptional repression activity, partially through the recruitment of the corepressor TRIM28 but has also repression activity independently of this interaction (PubMed:22110054, PubMed:27658112). Essential during embryonic development, where it acts as direct repressor of IGF2-P0, placental-specific transcript of IGF2, in early development and regulates convergent extension movements required for axis elongation and tissue morphogenesis in all germ layers (PubMed:18701545, PubMed:22110054, PubMed:28522536). Also important for normal morphogenesis of extraembryonic tissues including the yolk sac, extraembryonic mesoderm and placenta (PubMed:18701545, PubMed:21094155). May enhance proliferation or maintenance of neural stem cells (PubMed:23071813).^{[1] [2] [3] [4] [5]}

References

1. ↑ Garcia-Garcia MJ, Shibata M, Anderson KV. Chato, a KRAB zinc-finger protein, regulates convergent extension in the mouse embryo. Development. 2008 Sep;135(18):3053-62. doi: 10.1242/dev.022897. Epub 2008 Aug 13. PMID:18701545 doi:http://dx.doi.org/10.1242/dev.022897
2. ↑ Shibata M, Garcia-Garcia MJ. The mouse KRAB zinc-finger protein CHATO is required in embryonic-derived tissues to control yolk sac and placenta morphogenesis. Dev Biol. 2011 Jan 15;349(2):331-41. doi: 10.1016/j.ydbio.2010.11.015. Epub 2010 , Nov 19. PMID:21094155 doi:http://dx.doi.org/10.1016/j.ydbio.2010.11.015
3. ↑ Shibata M, Blauvelt KE, Liem KF Jr, Garcia-Garcia MJ. TRIM28 is required by the mouse KRAB domain protein ZFP568 to control convergent extension and morphogenesis of extra-embryonic tissues. Development. 2011 Dec;138(24):5333-43. doi: 10.1242/dev.072546. PMID:22110054 doi:http://dx.doi.org/10.1242/dev.072546
4. ↑ Chien HC, Wang HY, Su YN, Lai KY, Lu LC, Chen PC, Tsai SF, Wu CI, Hsieh WS, Shen CK. Targeted disruption in mice of a neural stem cell-maintaining, KRAB-Zn finger-encoding gene that has rapidly evolved in the human lineage. PLoS One. 2012;7(10):e47481. doi: 10.1371/journal.pone.0047481. Epub 2012 Oct 10. PMID:23071813 doi:http://dx.doi.org/10.1371/journal.pone.0047481
5. ↑ Murphy KE, Shylo NA, Alexander KA, Churchill AJ, Copperman C, Garcia-Garcia MJ. The Transcriptional Repressive Activity of KRAB Zinc Finger Proteins Does Not Correlate with Their Ability to Recruit TRIM28. PLoS One. 2016 Sep 22;11(9):e0163555. doi: 10.1371/journal.pone.0163555., eCollection 2016. PMID:27658112 doi:http://dx.doi.org/10.1371/journal.pone.0163555