Structural highlights
Publication Abstract from PubMed
The deoxynucleotide fragment d(GpGpCpCpGpGpCpC) was synthesized and crystallized, and its three-dimensional structure was determined by x-ray diffraction techniques to a resolution of 2.25 A. The molecule forms a right-handed double helix in which the two base pairs at either end of the molecule are in the conventional A-DNA conformation, while the central four base pairs have a modified form in which alternate residues have sugar conformations that are closer to those in B-DNA than in A-DNA. The molecules have an intermolecular contact in which the planar terminal guanine . cytosine base pair lies on the flat minor groove surface of the A-DNA helix.
Molecular structure of the octamer d(G-G-C-C-G-G-C-C): modified A-DNA.,Wang AH, Fujii S, van Boom JH, Rich A Proc Natl Acad Sci U S A. 1982 Jul;79(13):3968-72. PMID:6955784[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Wang AH, Fujii S, van Boom JH, Rich A. Molecular structure of the octamer d(G-G-C-C-G-G-C-C): modified A-DNA. Proc Natl Acad Sci U S A. 1982 Jul;79(13):3968-72. PMID:6955784
