1ao7
From Proteopedia
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| , resolution 2.6Å | |||||||
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| Ligands: | |||||||
| Gene: | HLA-A 0201 (Homo sapiens), V BETA 12.3 [BV13S1] - D BETA 2.1 - J BETA 2.1 - (Homo sapiens), V ALPHA 2.3 [AV2S1A2] - J ALPHA 24 - C ALPHA (Homo sapiens), V BETA 12.3 [BV13S1] - D BETA 2.1 - J BETA 2.1 - C BETA 2 (Homo sapiens) | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
COMPLEX BETWEEN HUMAN T-CELL RECEPTOR, VIRAL PEPTIDE (TAX), AND HLA-A 0201
Overview
Recognition by a T-cell antigen receptor (TCR) of peptide complexed with a major histocompatibility complex (MHC) molecule occurs through variable loops in the TCR structure which bury almost all the available peptide and a much larger area of the MHC molecule. The TCR fits diagonally across the MHC peptide-binding site in a surface feature common to all class I and class II MHC molecules, providing evidence that the nature of binding is general. A broadly applicable binding mode has implications for the mechanism of repertoire selection and the magnitude of alloreactions.
About this Structure
1AO7 is a Protein complex structure of sequences from Homo sapiens and Human t-lymphotropic virus 1. Full crystallographic information is available from OCA.
Reference
Structure of the complex between human T-cell receptor, viral peptide and HLA-A2., Garboczi DN, Ghosh P, Utz U, Fan QR, Biddison WE, Wiley DC, Nature. 1996 Nov 14;384(6605):134-41. PMID:8906788
Page seeded by OCA on Sun Mar 30 18:44:18 2008
