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1aol
From Proteopedia
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| , resolution 2.0Å | |||||||
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| Ligands: | , | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
FRIEND MURINE LEUKEMIA VIRUS RECEPTOR-BINDING DOMAIN
Overview
An essential step in retrovirus infection is the binding of the virus to its receptor on a target cell. The structure of the receptor-binding domain of the envelope glycoprotein from Friend murine leukemia virus was determined to 2.0 angstrom resolution by x-ray crystallography. The core of the domain is an antiparallel beta sandwich, with two interstrand loops forming a helical subdomain atop the sandwich. The residues in the helical region, but not in the beta sandwich, are highly variable among mammalian C-type retroviruses with distinct tropisms, indicating that the helical subdomain determines the receptor specificity of the virus.
About this Structure
1AOL is a Single protein structure of sequence from Friend murine leukemia virus. Full crystallographic information is available from OCA.
Reference
Structure of a murine leukemia virus receptor-binding glycoprotein at 2.0 angstrom resolution., Fass D, Davey RA, Hamson CA, Kim PS, Cunningham JM, Berger JM, Science. 1997 Sep 12;277(5332):1662-6. PMID:9287219
Page seeded by OCA on Sun Mar 30 18:44:32 2008
