WD repeat-containing protein

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spinqualitylabelsall models Human WD-repeat protein 5 (deepskyblue) complex with histone H3 peptide (magenta) (PDB code 2h9m) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Contents 1 Function 2 Disease 3 Structural highlights 4 3D Structures of WD-repeat protein Function WD repeat-containing proteins or ribosome biogenesis protein WDR (WDR) contain 4 or more repeating WD units. WD repeats are ca. 40 amino acid long usually bordered by Gly-His and Trp-Asp (WD). All WDRs form a β-propeller structure. WDRs have critical roles in many biological functions like signal transduction, transcription regulation and apoptosis[1]. WD-repeat protein 5 (WDR5) contains 7 WD repeats. WDR5 contributes to histone modification. It may position the N-terminal of histone H3 for efficient methylation at Lys4. This methylation is implicated in the control of activation of cell lineage genes during embryogenesis. WDR5 interacts with histone-lysine N-methyltransferase (MLL)[2]. WD repeat-containing protein 48 and 20 act as regulators of deubiquinating complexes. Disease Mutant WDR is involved in triple-A syndrome[3]. Structural highlights The of the WDR5 β-propellor structure acting like an anchoring pin [4]. Water molecules are shown as red spheres. 3D Structures of WD-repeat protein WD-repeat protein 3D structures

3D Structures of WD-repeat protein

Updated on 28-March-2020

References

1. ↑ Li D, Roberts R. WD-repeat proteins: structure characteristics, biological function, and their involvement in human diseases. Cell Mol Life Sci. 2001 Dec;58(14):2085-97. PMID:11814058
2. ↑ Gan Q, Thiebaud P, Theze N, Jin L, Xu G, Grant P, Owens GK. WD repeat-containing protein 5, a ubiquitously expressed histone methyltransferase adaptor protein, regulates smooth muscle cell-selective gene activation through interaction with pituitary homeobox 2. J Biol Chem. 2011 Jun 17;286(24):21853-64. doi: 10.1074/jbc.M111.233098. Epub, 2011 Apr 28. PMID:21531708 doi:http://dx.doi.org/10.1074/jbc.M111.233098
3. ↑ Tullio-Pelet A, Salomon R, Hadj-Rabia S, Mugnier C, de Laet MH, Chaouachi B, Bakiri F, Brottier P, Cattolico L, Penet C, Begeot M, Naville D, Nicolino M, Chaussain JL, Weissenbach J, Munnich A, Lyonnet S. Mutant WD-repeat protein in triple-A syndrome. Nat Genet. 2000 Nov;26(3):332-5. PMID:11062474 doi:http://dx.doi.org/10.1038/81642
4. ↑ Schuetz A, Allali-Hassani A, Martin F, Loppnau P, Vedadi M, Bochkarev A, Plotnikov AN, Arrowsmith CH, Min J. Structural basis for molecular recognition and presentation of histone H3 by WDR5. EMBO J. 2006 Sep 20;25(18):4245-52. Epub 2006 Aug 31. PMID:16946699