Structural highlights
Publication Abstract from PubMed
Turnip mosaic virus (TuMV), a potyvirus, is a flexible filamentous plant virus that displays a helical arrangement of coat protein copies (CPs) bound to the ssRNA genome. TuMV is a bona fide representative of the Potyvirus genus, one of most abundant groups of plant viruses, which displays a very wide host range. We have studied by cryoEM the structure of TuMV virions and its viral-like particles (VLPs) to explore the role of the interactions between proteins and RNA in the assembly of the virions. The results show that the CP-RNA interaction is needed for the correct orientation of the CP N-terminal arm, a region that plays as a molecular staple between CP subunits in the fully assembled virion.
Structure of Turnip mosaic virus and its viral-like particles.,Cuesta R, Yuste-Calvo C, Gil-Carton D, Sanchez F, Ponz F, Valle M Sci Rep. 2019 Oct 28;9(1):15396. doi: 10.1038/s41598-019-51823-4. PMID:31659175[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Cuesta R, Yuste-Calvo C, Gil-Carton D, Sanchez F, Ponz F, Valle M. Structure of Turnip mosaic virus and its viral-like particles. Sci Rep. 2019 Oct 28;9(1):15396. doi: 10.1038/s41598-019-51823-4. PMID:31659175 doi:http://dx.doi.org/10.1038/s41598-019-51823-4
