Phospholysine phosphohistidine inorganic pyrophosphate phosphatase (LHPP)* is a hydrolase enzyme which is known to be expressed in the liver, kidney, and at moderate levels in the brain[1]. It belongs to the haloacid dehalogenase (HAD) superfamily of hydrolases with hydrolyze a wide variety of substrates[2].
The HAD Superfamily
HAD Phosphatases: Mechanism & Structure
LHPP-Specific Mechanisms & Structure
Role in Disease
Major Depressive Disorder
Cancer
Thyroid Diseases
References
- ↑ Gohla A. Do metabolic HAD phosphatases moonlight as protein phosphatases? Biochim Biophys Acta Mol Cell Res. 2019 Jan;1866(1):153-166. doi:, 10.1016/j.bbamcr.2018.07.007. Epub 2018 Jul 18. PMID:30030002 doi:http://dx.doi.org/10.1016/j.bbamcr.2018.07.007
- ↑ Seifried A, Schultz J, Gohla A. Human HAD phosphatases: structure, mechanism, and roles in health and disease. FEBS J. 2013 Jan;280(2):549-71. doi: 10.1111/j.1742-4658.2012.08633.x. Epub 2012 , Jun 13. PMID:22607316 doi:http://dx.doi.org/10.1111/j.1742-4658.2012.08633.x
