Rhodocetin

From Proteopedia

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spinqualitylabelsall models PDB ID 3gpr Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image PMID:10360956</ref>. Relevance Rhodocetin subunits αβ which selectively attacks tumor blood vessels and spares normal tissue vessels is studied as an anti-tumor[1]. Structural highlights

3D structures of rhodocetin

Updated on 23-April-2020

1sb2 - MpvRtn subunits αβ - Malayan pit viper
3gpr - MpvRtn subunits αβγδ
6nde, 6ndd, 6ndf, 6ndh, 6nda, 6ndc, 6ndb, 6nd8, 6ndg, 6nd9, 5thp - MpvRtn subunits γδ + integrin α-2 + ion

References

1. ↑ Niland S, Komljenovic D, Macas J, Bracht T, Bauerle T, Liebner S, Eble JA. Rhodocetin-alphabeta selectively breaks the endothelial barrier of the tumor vasculature in HT1080 fibrosarcoma and A431 epidermoid carcinoma tumor models. Oncotarget. 2018 Apr 27;9(32):22406-22422. doi: 10.18632/oncotarget.25032., eCollection 2018 Apr 27. PMID:29854288 doi:http://dx.doi.org/10.18632/oncotarget.25032