Increased sodium tolerance protein

From Proteopedia

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spinqualitylabelsall models Caption for this structure Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Contents 1 Function 2 Disease 3 Relevance 4 Structural highlights Function Increased sodium tolerance protein 1 (Ist1) is a family member of the transport-III (ESCRT-III) forming high-order helical structures with CHMP1B which are required in remodeling membranes during abscission[1]. Increased sodium tolerance protein 3 (Ist3) or U2 snRNP component IST3 (Ist3) is part of the spliceosome which is involved in transcription and pre-mRNA splicing. Ist3 interacts with human elongation factors and strongly stimulates polymerase elongation[2]. Disease Somatic mutations in Ist3 have been found in various malignancies like breast cancer, pancreatuc cancer, uveal melanoma and others[3]. Relevance Structural highlights

3D structures of increased sodium tolerance protein

Updated on 19-May-2020

References

1. ↑ Bajorek M, Schubert HL, McCullough J, Langelier C, Eckert DM, Stubblefield WM, Uter NT, Myszka DG, Hill CP, Sundquist WI. Structural basis for ESCRT-III protein autoinhibition. Nat Struct Mol Biol. 2009 Jul;16(7):754-62. Epub 2009 Jun 14. PMID:19525971 doi:10.1038/nsmb.1621
2. ↑ Fong YW, Zhou Q. Stimulatory effect of splicing factors on transcriptional elongation. Nature. 2001 Dec 20-27;414(6866):929-33. PMID:11780068 doi:http://dx.doi.org/10.1038/414929a
3. ↑ Tanikawa M, Sanjiv K, Helleday T, Herr P, Mortusewicz O. The spliceosome U2 snRNP factors promote genome stability through distinct mechanisms; transcription of repair factors and R-loop processing. Oncogenesis. 2016 Dec 19;5(12):e280. doi: 10.1038/oncsis.2016.70. PMID:27991914 doi:http://dx.doi.org/10.1038/oncsis.2016.70