Structural highlights
Disease
[NUMA1_HUMAN] Acute promyelocytic leukemia.
Function
[NUMA1_HUMAN] Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority if the nuclear volume. Required for maintenance and establishment of the mitotic spindle poles, functionning as a tether linking bulk microtubules of the spindle to centrosomes. May be involved in coordination of the alignment of the mitotic spindle to the cellular polarity axis, which is a prerequisite for asymmetric cell divisions.[1]
References
- ↑ Silk AD, Holland AJ, Cleveland DW. Requirements for NuMA in maintenance and establishment of mammalian spindle poles. J Cell Biol. 2009 Mar 9;184(5):677-90. doi: 10.1083/jcb.200810091. Epub 2009 Mar , 2. PMID:19255246 doi:http://dx.doi.org/10.1083/jcb.200810091
