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1bg7
From Proteopedia
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| , resolution 1.85Å | |||||||
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| Ligands: | |||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
LOCALIZED UNFOLDING AT THE JUNCTION OF THREE FERRITIN SUBUNITS. A MECHANISM FOR IRON RELEASE?
Overview
How and where iron exits from ferritin for cellular use is unknown. Twenty-four protein subunits create a cavity in ferritin where iron is concentrated >10(11)-fold as a mineral. Proline substitution for conserved leucine 134 (L134P) allowed normal assembly but increased iron exit rates. X-ray crystallography of H-L134P ferritin revealed localized unfolding at the 3-fold axis, also iron entry sites, consistent with shared use sites for iron exit and entry. The junction of three ferritin subunits appears to be a dynamic aperture with a "shutter" that cytoplasmic factors might open or close to regulate iron release in vivo.
About this Structure
1BG7 is a Single protein structure of sequence from Rana catesbeiana. Full crystallographic information is available from OCA.
Reference
Localized unfolding at the junction of three ferritin subunits. A mechanism for iron release?, Takagi H, Shi D, Ha Y, Allewell NM, Theil EC, J Biol Chem. 1998 Jul 24;273(30):18685-8. PMID:9668036
Page seeded by OCA on Sun Mar 30 19:00:17 2008
