Structural highlights
Publication Abstract from PubMed
The crystal structure of a DNA duplex with tricyclo-DNA (tc-DNA) residues explains the increased RNA affinity of tc-DNA relative to DNA and tc-DNA's superior resistance to nucleases.
Crystal structure of tricyclo-DNA: an unusual compensatory change of two adjacent backbone torsion angles.,Pallan PS, Ittig D, Heroux A, Wawrzak Z, Leumann CJ, Egli M Chem Commun (Camb). 2008 Feb 21;(7):883-5. Epub 2007 Dec 21. PMID:18253536[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Pallan PS, Ittig D, Heroux A, Wawrzak Z, Leumann CJ, Egli M. Crystal structure of tricyclo-DNA: an unusual compensatory change of two adjacent backbone torsion angles. Chem Commun (Camb). 2008 Feb 21;(7):883-5. Epub 2007 Dec 21. PMID:18253536 doi:10.1039/b716390h
