| Theoretical Model:
The protein structure described on this page was determined theoretically, and hence should be interpreted with caution. |
Function
Protein E
Plays a central role in virus morphogenesis and assembly. Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. Also plays a role in the induction of apoptosis. Activates the host NLRP3 inflammasome, leading to IL-1beta overproduction.[1][2]
Disease
Relevance
Structural highlights
