User:Eric Martz/Antibody Quiz

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Antibody Quiz

You will get immediate feedback when you click Submit (at the bottom of the quiz). The quiz below is offered to accompany the Antibody structure tutorial at MolviZ.Org. For the open-ended questions provided with the tutorial, answers are below.


1. How many "arms" does one antibody molecule have?

→

2.

How many Fab "arms" does one antibody molecule have?
→

3.

How many Fc "arms" does one antibody molecule have?
→

4.

How many CDRs are in one paratope?
→ Three in the light chain variable domain plus three in the heavy chain variable domain.

5.

What is the term for the smallest part of IgG1 that binds to antigen?
→ The variable fragment, containing only the variable domains: Fv.

An IgG1 molecule has a molecular weight of 150 kilo Daltons.

6.

What is the approximate molecular weight of one immunoglobulin domain in kD?
kD.
→ Twelve Ig domains in one IgG1 molecule. 150/12 = 12.5 kD.

7.

What is the approximate molecular weight of a single Fc in kD?
kD.
→ Fc is one of three roughly equal-sized arms, each containing 8 Ig domains. 150/3 = 50 kD.

Questions below may have more than one correct answer.


8. Antibody

Binds to antigen.
When bound to a microbe, recruits macrophages and other leukocytes to kill the microbes.
Defends us against infections.
Carries oxygen to tissues.
Is a hormone.
Strengthens bones.

9. Antibody molecules consist of

Protein.
Lipid.
Salt.
Sugars.
Carbohydrate.
Amino acids.
Fatty acids.
Immunoglobulin domains.

10. Antibody is manufactured by

T lymphocytes.
The liver.
B lymphocytes.
Antigen.
G lymphocytes.
Macrophages.

11. Variable immunoglobulin domains

Are in Fab.
Are in Fc.
Are in all antibodies.
Have no disulfide bonds.
Do not contain CDRs.
Make up the epitope.
Make up the paratope.
Have the same amino acid sequence in all antibodies of a given subclass.

12. A single immunoglobulin domain contains

Three beta sheets.
Two beta sheets.
One beta sheet.
Two alpha helices.
One alpha helix.
One disulfide bond.
Two disulfide bonds.
A hydrophilic core.
A hydrophobic core.

13. Which CDRs contribute the most to antigen specificity?

Light chain CDRs.
Heavy chain CDRs.
CDR1s.
CDR2s.
CDR3s.
CDR4s.

Your score is 0 / 0

Suggestions to emartz at microbio dot umass dot edu.

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Proteopedia Page Contributors and Editors (what is this?)

Eric Martz

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