1c4p

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Image:1c4p.gif


PDB ID 1c4p

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, resolution 2.4Å
Related: 1BML


Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



BETA DOMAIN OF STREPTOKINASE


Overview

Streptokinase, a 47 kDa secreted protein of hemolytic strains of streptococci, is a human plasminogen activator and contains three structural domains linked by flexible loops. We describe here the crystal structure of the isolated streptokinase middle (SKbeta) domain determined at 2.4 A resolution. Among the functionally important structural features is a putative binding site for a kringle domain of plasminogen located at the tip of a fully exposed hairpin loop. The distribution of genetically conserved residues of SKbeta is strongly correlated with their functions. The extensive interface of the SKbeta dimer suggests that such dimers may also exist in solution for free SKbeta.

About this Structure

1C4P is a Single protein structure of sequence from Streptococcus dysgalactiae subsp. equisimilis. Full crystallographic information is available from OCA.

Reference

Crystal structure of streptokinase beta-domain., Wang X, Tang J, Hunter B, Zhang XC, FEBS Lett. 1999 Oct 1;459(1):85-9. PMID:10508922

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