Structural highlights
5m1z is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Ligands: | , , , , , |
| Activity: | Non-reducing end alpha-L-arabinofuranosidase, with EC number 3.2.1.55 |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Publication Abstract from PubMed
The synthesis of potent inhibitors of GH93 arabinanases as well as a synthesis of a chromogenic substrate to measure GH93 arabinanase activity is described. An insight into the reasons behind the potency of the inhibitors was gained through X-ray crystallographic analysis using the arabinanase Arb93A from Fusarium graminearum. These compounds lay a foundation for future inhibitor development as well as for the use of the chromogenic substrate in biochemical studies of GH93 arabinanases.
Exploiting sp2-hybridization in the development of potent 1,5-a-L-arabinanase inhibitors.,Coyle T, Debowski A, Varrot A, Stubbs KA Chembiochem. 2017 Mar 7. doi: 10.1002/cbic.201700073. PMID:28266777[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Coyle T, Debowski A, Varrot A, Stubbs KA. Exploiting sp2-hybridization in the development of potent 1,5-a-L-arabinanase inhibitors. Chembiochem. 2017 Mar 7. doi: 10.1002/cbic.201700073. PMID:28266777 doi:http://dx.doi.org/10.1002/cbic.201700073
