Structural highlights
5mha is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Ligands: | , , , , , |
| Related: | 5mh5, 5mh6 |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Function
[DDH_HALMT] Catalyzes the stereospecific NAD(P)H-dependent reduction of 2-ketocarboxylic acids into the corresponding D-2-hydroxycarboxylic acids. Can use both NADPH or NADH as reductant, displaying a marked preference for NADPH over NADH. Shows a broad substrate specificity, although it displays a marked preference for the 2-ketocarboxylic acids having an unbranched chain of 4-5 carbon atoms.[1]
References
- ↑ Domenech J, Ferrer J. A new D-2-hydroxyacid dehydrogenase with dual coenzyme-specificity from Haloferax mediterranei, sequence analysis and heterologous overexpression. Biochim Biophys Acta. 2006 Nov;1760(11):1667-74. doi:, 10.1016/j.bbagen.2006.08.024. Epub 2006 Sep 6. PMID:17049749 doi:http://dx.doi.org/10.1016/j.bbagen.2006.08.024
