Structural highlights
Publication Abstract from PubMed
Zika virus is considered a major global threat to human kind. Here, we present a crystal structure of one of its essential enzymes, the methyltransferase, with the inhibitor sinefungin. This structure, together with previously solved structures with bound substrates, will provide the information needed for rational inhibitor design. Based on the structural data we suggest the modification of the adenine moiety of sinefungin to increase selectivity and to covalently link it to a GTP analogue, to increase the affinity of the synthesized compounds.
Structural basis of Zika virus methyltransferase inhibition by sinefungin.,Hercik K, Brynda J, Nencka R, Boura E Arch Virol. 2017 Mar 29. doi: 10.1007/s00705-017-3345-x. PMID:28357511[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Hercik K, Brynda J, Nencka R, Boura E. Structural basis of Zika virus methyltransferase inhibition by sinefungin. Arch Virol. 2017 Mar 29. doi: 10.1007/s00705-017-3345-x. PMID:28357511 doi:http://dx.doi.org/10.1007/s00705-017-3345-x
