6mf4

Structural highlights

Function

[CDC5_YEAST] Protein kinase required for the cell cycle where it is involved in mitotic exit. A component of the fear (CDC14 early anaphase release) network which promotes CDC14 release from the nucleolus during early anaphase. Phosphorylates SCC1/MCD1 and NET1.^{[1] [2] [3]}

References

1. ↑ Alexandru G, Uhlmann F, Mechtler K, Poupart MA, Nasmyth K. Phosphorylation of the cohesin subunit Scc1 by Polo/Cdc5 kinase regulates sister chromatid separation in yeast. Cell. 2001 May 18;105(4):459-72. PMID:11371343
2. ↑ Stegmeier F, Visintin R, Amon A. Separase, polo kinase, the kinetochore protein Slk19, and Spo12 function in a network that controls Cdc14 localization during early anaphase. Cell. 2002 Jan 25;108(2):207-20. PMID:11832211
3. ↑ Yoshida S, Toh-e A. Budding yeast Cdc5 phosphorylates Net1 and assists Cdc14 release from the nucleolus. Biochem Biophys Res Commun. 2002 Jun 14;294(3):687-91. doi:, 10.1016/S0006-291X(02)00544-2. PMID:12056824 doi:http://dx.doi.org/10.1016/S0006-291X(02)00544-2