Sandbox GGC5

Heart-type Fatty acid-binding proteins (H-FABP/FABP3) are cytoplasmic carrier protein that active fatty acid metabolism in the heart; found in cardiomyocytes.

Function

Heart-type fatty acid binding protein (H-FABP) found in heart and skeletal muscle tissue. FABP3 involved in fatty acid metabolism by myristic acid. Myristic acid is long saturated fatty acid chain that found in plant and animal, especially in milk fat. It produced during human metabolism and binds with FAPB3. Hexaethylene glycol used in crystallized FABP3 with myristic acid.

Disease

Pulmonary Embolism is lung disease that occurs when blood clots block the one of the pulmonary arteries. It blocks blood and oxygen flow and can causes pulmonary infarction when it gets severe.
Acute Myocardial Infarction is heart attack that due to cholesterol, saturated fat, and trans-fat build plaque and block the arteries which causes cardio tissue damage.

Structure

Lysine (orange), arginine (turquoise), tyrosine (purple), and serine (yellow)
Tyr128 formed hydrogen bond with O2 of MYR and epsilon nitrogen and one of NH2 of Arg128 formed hydrogen bond with hydroxyl MYR.
Lys37 formed hydrogen bond with 4 oxygens (1,4,7, and 10) of P6G and ketone group of Ser34 formed hydrogen bond with hydroxyl group of P6G.