Structure
The structure of the has a pseudo-symmetry within its structure which contains two 88-amino acid repeats. The of this protein include both Alpha and Beta components on the distribution of the symmetry. This structure attaches to a DNA structure of deformity in the helix; the deformity is for the purpose of binding. The DNA structure's show the minor groove is wide open to have complete access for the TBP to bind within it (2). Some interactions are with the minor groove, and some interactions are with the sugar/ phosphate helix within the backbone.
Function
The TATA-Binding protein, TBP, is a factor in the process of Transcription within Eukaryotes. This binding protein is a subunit in the family of TFIID. The function of the TBP is to bind to a DNA sequence which is the TATA box. The shows the protein (the TATA-Binding Protein) attaching to the DNA sequence (the TATA box). This allows RNA Polymerase II to bind to the promoter. This is the beginning of the process of Transcription (3).
Relevance
The TATA-Binding Protein is relevant to everyday life because humans contain this specific protein as well with or without a promoter. This process is happening in multiple tissues and cells at a time (1). Although it may not have any diseases
connected with it, the protein is needed in everyday life.
Interesting Facts about the TBP
-The first ever for the TBP was found in fruit flies, specifically Drosophila flies.
-This is not the same idea in prokaryotes. Prokaryotes have a different concept because it is a Pribnow box instead of a TATA box (2).
-Another name for the TATA box is the Goldberg-Hogness box (1).
