| Structural highlights
Function
[PE05_MYCTU] Important for the siderophore-mediated iron-acquisition function of ESX-3 (PubMed:26729876). May play a pivotal role in the evasion of host immune response by M.tuberculosis. Mediates production of IL-10 via activation of the p38 and ERK1/2 mitogen-activated protein kinase (MAPK) signaling pathways (PubMed:23284742).[1] [2] [PPE04_MYCTU] Important for the siderophore-mediated iron-acquisition function of ESX-3.[3]
References
- ↑ Tiwari BM, Kannan N, Vemu L, Raghunand TR. The Mycobacterium tuberculosis PE proteins Rv0285 and Rv1386 modulate innate immunity and mediate bacillary survival in macrophages. PLoS One. 2012;7(12):e51686. doi: 10.1371/journal.pone.0051686. Epub 2012 Dec 17. PMID:23284742 doi:http://dx.doi.org/10.1371/journal.pone.0051686
- ↑ Tufariello JM, Chapman JR, Kerantzas CA, Wong KW, Vilcheze C, Jones CM, Cole LE, Tinaztepe E, Thompson V, Fenyo D, Niederweis M, Ueberheide B, Philips JA, Jacobs WR Jr. Separable roles for Mycobacterium tuberculosis ESX-3 effectors in iron acquisition and virulence. Proc Natl Acad Sci U S A. 2016 Jan 19;113(3):E348-57. doi:, 10.1073/pnas.1523321113. Epub 2016 Jan 4. PMID:26729876 doi:http://dx.doi.org/10.1073/pnas.1523321113
- ↑ Tufariello JM, Chapman JR, Kerantzas CA, Wong KW, Vilcheze C, Jones CM, Cole LE, Tinaztepe E, Thompson V, Fenyo D, Niederweis M, Ueberheide B, Philips JA, Jacobs WR Jr. Separable roles for Mycobacterium tuberculosis ESX-3 effectors in iron acquisition and virulence. Proc Natl Acad Sci U S A. 2016 Jan 19;113(3):E348-57. doi:, 10.1073/pnas.1523321113. Epub 2016 Jan 4. PMID:26729876 doi:http://dx.doi.org/10.1073/pnas.1523321113
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