5t3u

Publication Abstract from PubMed

Streptococcus pneumoniae harbors a significant number of transporters, including phosphotransferase (PTS) systems, allowing the bacterium to utilize a number of different carbohydrates for metabolic and other purposes. The genes encoding for one PTS transport system in particular (EIIfuc ) are found within a fucose utilization operon in S. pneumoniae TIGR4. Here, we report the 3-dimensional structures of IIAfuc and IIBfuc providing evidence that this PTS system belongs to the EIIman family. Additionally, the predicted metabolic pathway for this distinctive fucose utilization system suggests that EIIfuc transports the H-disaccharide blood group antigen, which would represent a novel PTS transporter specificity. This article is protected by copyright. All rights reserved.

Structural characterization of the PTS IIA and IIB proteins associated with pneumococcal fucose utilization.,Higgins MA, Hamilton AM, Boraston AB Proteins. 2017 Feb 7. doi: 10.1002/prot.25264. PMID:28168775^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.